Abstract #0787

Towards short dipolar relaxation time, T1D, MRI

Gopal Varma¹, Patricia Coutinho de Souza¹, Valentin H Prevost², Olivier M Girard², Victor Carvalho², Samira Mchinda², Leo Tsai¹, Guillaume Duhamel², Aaron K Grant¹, and David C Alsop¹

¹Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ²CNRS, CRMBM, UMR 7339, Aix Marseille Universite, Marseille, France

The inhomogeneous magnetization transfer (ihMT) technique has shown myelin sensitivity, and is understood to be dependent on power and the dipolar relaxation time parameter, T_1D, which is longer in myelinated tissues. Implementation of ihMT can be adapted to provide a smaller, but non-negligible signal from other, relatively short T_1D tissues. Simulations showed a measurable ihMT signal, achieved from fixed low duty cycle MT preparations with high B₁ pulses, decayed with pulse width at a rate dependent on T_1D. Thus short, high B₁ pulses were implemented to acquire ihMT data from ex-vivo samples of rat heart, kidney, and tail tendon, demonstrating the feasibility of short T_1D imaging.

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