Meeting Banner
Abstract #0788

MT-Based Detection of Semi-Solids without Background Water Signal.

Peter van Gelderen1, Jacco A de Zwart1, and Jeff H Duyn1

1AMRI, LFMI, NINDS, NIH, Bethesda, MD, United States

Brain tissue can be modeled as a system with a water pool and an invisible pool of semi-solids. The exchange between these pools can be measured by saturating the semi-solids and observing the decrease in water signal after exchange. This requires making a differential measurement, comparing data with and without saturation. Here we present a variation of the STEAM sequence, adding water suppression, which allows for observation of exchanging spins in a single acquisition without a water background signal. The method was demonstrated in both a phantom and human subject at 3 T.

This abstract and the presentation materials are available to members only; a login is required.

Join Here