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Abstract #1060

MEGA-SPICE: A subspace-based approach to high-resolution spectral edited MRSI

Chao Ma1, Paul Kyu Han1, Shuang Hu1,2, and Georges El Fakhri1

1Gordon Center for Medical Imaging, Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2Nuclear Medicine, West China Hospital, Sichuan University, Sichuan, China

Spectral edited MRS/MRSI is a powerful tool to detect metabolites with J-coupled spins (e.g., GABA and 2-HG) that are otherwise overlapped with other high concentration metabolites (e.g., Cho and Cr). Compared to conventional MRSI, it is even more challenging to achieve high-resolution spectral edited MRSI because of lower metabolite concentration and less time-efficient spatial-spectral encoding. A subspace-based approach, called SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation), has been proposed for high-resolution MRSI, producing 3D MRSI images at 3 mm isotropic resolution within 10 mins. We present here a method, termed MEGA-SPICE, for accelerated high-resolution spectral edited MRSI, which is enabled by spectral editing using MEGA pulses and subspace-based data acquisition and processing strategies.

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