Proton MRSI has great clinical potential for metabolic mapping of healthy and pathological human brain. However, technical challenges related to poor spectral quality caused by magnetic field inhomogeneity, limited RF transmit power and incomplete lipid suppression have dampened the utility of MRSI. Here a novel method for lipid suppression is presented based on localization of an elliptical region-of-interest using pulsed second-order magnetic fields. A high-amplitude gradient setup was designed and constructed, containing coils to generate Z2, X2Y2 and XY magnetic fields. Simulations, phantom MRI and MRSI on human brain in vivo demonstrate robust localization and suppression of extracranial lipids.
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