Abstract #1191

Interleaved scanning for MR-guided High Intensity Focused Ultrasound mediated drug delivery

Edwin Heijman¹, Esther Kneepkens², Jochen Keupp³, Steffen Weiss³, and Holger Grüll⁴

¹Oncology Solutions, Philips Research, Cologne, Germany, ²Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, ³Philips Research, Hamburg, Germany, ⁴Department of Radiology, Experimental Imaging and Image-guided Therapy, University Hospital of Cologne, Cologne, Netherlands

MR-guided High Intensity Focused Ultrasound (MR-HIFU) is a method that allows non-invasive heating of lesions to well-controlled ablative or hyperthermic temperatures. Control of acoustic power and focus position is achieved using a feedback based on MR thermometry. Local hyperthermia can be used as a trigger for image guided drug delivery using temperature sensitive liposomes co-encapsulating doxorubicin and MR contrast agent. The challenge is to acquire both temperature and R₁-maps during hyperthermia dynamically. We investigated a novel MR method interleaving both acquisitions, with their own temporal resolution, without compromising temperature feedback showing a gradually increase of contrast agent inside rat tumors.

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