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Abstract #1192

An experimental model for mild hyperthermia with predictive temperature control in osteolytic bone metastases, using MR-guided focused ultrasound.

Sana Boudabbous1, Pauline Guillemin1, Orane Lorton1, Laura Gui-Levy1, Stephane Desgranges1, Xavier Montet1, Christoph D Becker1, Raymond Miralbell2, Thomas Zilli2, and Rares Salomir1

1Radiology, Geneva University Hospitals, Image guided Interventions Laboratory, Geneva, Switzerland, 2Radiation Oncology, Geneva University Hospitals, Geneva, Switzerland

Combination of hyperthermia with ionizing radiation is strongly compelling, based on principles of classic radiobiology, molecular biology, and tumor physiology. MR-guided focused ultrasound (MRgFUS) is a “touch-less” approach already employed for ablative pain palliation of symptomatic bone metastases (SBM). MRgFUS mild hyperthermia adjuvant to radiation therapy has not been reported for SMB pain palliation. We optimized here the geometry of MRgFUS sonication and the automatic temperature control during steady-state long lasting hyperthermia using a realistic ex-vivo anatomic model mimicking osteolytic bone tumors. The results demonstrated uniform spatio-temporal heating, together with predictable and safe thermal condition of the cortical bone.

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