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Abstract #1262

Applying T2 Relaxation Under Spin Tagging (TRUST) to assess renal oxygenation in the kidney

Alexander J Daniel1, Eleanor F Cox1, Charlotte E Buchanan1, Chris R Bradley 1, and Susan T Francis1

1Sir Peter Mansfield Imaging Centre, The University of Nottingham, Nottingham, United Kingdom

T2 Relaxation Under Spin Tagging (TRUST) provides a method to measure oxygenation in venous vessels within the brain. Here, a TRUST scheme is adapted for use within the body, specifically to assess oxygenation in the renal vein, using a respiratory-triggered Flow-sensitive Alternating Inversion Recovery (FAIR) labelling technique. This FAIR-TRUST variant has been tested in the brain, its reproducibility assessed in the kidney, and used to measure a change in blood oxygenation during an oxygen challenge. Changes in renal vein oxygenation could be measured more robustly than changes in BOLD T2*, the current MRI standard tissue oxygenation assessment within the kidney.

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