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Abstract #1318

Quantification of Glutamate and Glutamine in the healthy brain via 1H in-vivo CSI MRS using LCModel is not reliable.

Simon Maennlin1, Rupert Kolb1, Anja Stierl1, and Uwe Klose1

1Departement of Diagnostic and Interventional Neuroradiology, University Hospital Tuebingen, Tuebingen, Germany

Glutamate and glutamine play an important role in CNS. Both are quantifiable via 1H in-vivo MRS, although a correct, separate quantification of both metabolites is often very challenging. In this study, 1H in-vivo CSI MRS was performed on ten healthy subjects, using the CSI sequences PRESS and Semi-LASER with TE=40ms,60ms,80ms,100ms and 135ms at 3T. The inner 64 spectra of each CSI matrix at each TE were averaged to a single spectrum. Averaged spectra were analysed using LCModel. The quantification of glutamate and glutamine, using this method, which is also a popular approach in MRS research, was shown to be inconsistent.

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