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Abstract #1501

Simultaneous displacement and T2 mapping of High-intensity focused ultrasound therapy

Yangzi Qiao1, Chao Zou1, Zongwei Xu1,2, Chuanli Cheng1,3, Qian Wan1, Changjun Tie1, Xin Liu1, and Hairong Zheng1

1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Zhengzhou University, Zhengzhou, China, 3University of Chinese Academy of Sciences, Beijing, China

In this work, a hybrid ARFI sequence based on segmented SE-EPI is proposed to simultaneously monitor the displacement and T2 change of tissue during HIFU therapy. The reliability of this sequence was validated first. The quantified displacement and T2 show good consistence with the reference ARFI and SE results. The hybrid sequence was then applied before and after HIFU therapy to evaluate the treatment effects. With the occurrence of ablative lesion, T2 relaxation time decreased in the lesion center and increased in the boundary. While the displaced region (region with obvious displacement) and the maximal displacement at focus both enlarged. In general, this hybrid ARFI is a potentially useful HIFU monitoring method in clinical application.

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