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Abstract #1502

Monitoring of Acute Thermal Coagulation in Muscle Using PSIF Sequence in MRI-Guided High-Intensity Focused Ultrasound Therapy

Changjun Tie1, Chao Zou1, Qian Wan1,2, Yangzi Qiao1, Chuanli Cheng1,2, Xin Liu1, and Hairong Zheng1

1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, GuangDong, China, 2University of Chinese Academy of Sciences, Beijing, China

MR-guided high intensity focused ultrasound (MRgHIFU) is a new noninvasive approach for thermal ablation of focal lesions with clinical applications in uterus, bone, prostate, brain, breast, and liver.Traditionally, the volume of tissue coagulation is evaluated through contrast enhanced T1-weighted images (CET1). However, there are several limitations for CET1 used for thermal lesion detection.

In this study, acute thermal damage following HIFU ablation in muscle was assessed using a PSIF images. this preclinical study demonstrates that PSIF sequence offers a good T2 contrast for visualizing acute thermal damage in muscle tissue during HIFU treatment, and has an obvious advantage in acquisition time, making PSIF a suitable sequence for real-time monitoring tissue changes during thermotherapy at high field system.

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