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Abstract #1522

Brain metastases developing pseudoprogression have poor vascular function and supply

Ingrid Digernes1, Endre Grøvik1, Line B. Nilsen1, Cathrine Saxhaug2, Oliver Geier1, Edmund Reitan2, Dag Ottar Sætre3, Birger Breivik4, Kari Dolven Jacobsen5, Åslaug Helland5, and Kyrre Eeg Emblem1

1Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway, 2Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 3Department of Radiology, Østfold Hospital Trust, Kalnes, Norway, 4Deptartment of Radiology, Hospital of Southern Norway, Kristiansand, Norway, 5Department of Oncology, Oslo University Hospital, Oslo, Norway

Stereotactic radiosurgery of brain metastases can cause pseudoprogression. In this study, we use Vessel Architectural Imaging, based on dual echo DSC, to investigate the course of vascular function of brain metastases, both prior to and after pseudoprogression have occurred. Our results show that pseudoprogressing metastases were characterized by underperfused and oxygen-deprived tissue, and micro- and macrovessel pruning in the peritumoral regions. This was in contrast to peritumoral regions of responding metastases as well as normal-appearing brain tissue.

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