Abstract #1522

Brain metastases developing pseudoprogression have poor vascular function and supply

Ingrid Digernes¹, Endre Grøvik¹, Line B. Nilsen¹, Cathrine Saxhaug², Oliver Geier¹, Edmund Reitan², Dag Ottar Sætre³, Birger Breivik⁴, Kari Dolven Jacobsen⁵, Åslaug Helland⁵, and Kyrre Eeg Emblem¹

¹Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway, ²Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, ³Department of Radiology, Østfold Hospital Trust, Kalnes, Norway, ⁴Deptartment of Radiology, Hospital of Southern Norway, Kristiansand, Norway, ⁵Department of Oncology, Oslo University Hospital, Oslo, Norway

Stereotactic radiosurgery of brain metastases can cause pseudoprogression. In this study, we use Vessel Architectural Imaging, based on dual echo DSC, to investigate the course of vascular function of brain metastases, both prior to and after pseudoprogression have occurred. Our results show that pseudoprogressing metastases were characterized by underperfused and oxygen-deprived tissue, and micro- and macrovessel pruning in the peritumoral regions. This was in contrast to peritumoral regions of responding metastases as well as normal-appearing brain tissue.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.