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Abstract #1728

High Definition Sodium (23Na) In Vivo MRI of the Human Eye at 7.0 Tesla: Need for Substantially Enhanced Spatial Resolution than Commonly Used in Brain MRI

Daniel Wenz1, Andre Kuehne2, Till Huelnhagen1, Armin M. Nagel3,4, Helmar Waiczies2, Oliver Stachs5, Erdmann Seeliger6, Bert Flemming6, and Thoralf Niendorf1,2

1Berlin Ultrahigh Field Facility, Max Delbrueck Centrum, Berlin, Germany, 2MRI.TOOLS GmbH, Berlin, Germany, 3Institute of Radiology, Unviersity Hospital Erlangen, Erlangen, Germany, 4Division of Medical Physics in Radiology, German Research Centre (DKFZ), Heidelberg, Germany, 5Department of Ophthalmology, University of Rostock, Rostock, Germany, 6Institute of Physiology, Charite University Medicine, Berlin, Germany

Sodium ions are crucial in the physiology of human eye and its compartments like vitreous humor, aqueous humor, lens and retina. In this work we used a six-channel transceiver array dedicated for ocular 23Na MRI and obtained in vivo images of the eye of exceptional quality with enhanced spatial resolution like (1.0x1.0x1.0) mm3 and demonstrated why spatial resolutions currently used for sodium MRI of the human brain are not sufficient in the context of 23Na in vivo MRI of the human eye. Enhancing spatial resolution is essential to investigate changes of sodium concentration in subtle eye compartments (aqueous humor, lens).

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