Abstract #1728

High Definition Sodium (23Na) In Vivo MRI of the Human Eye at 7.0 Tesla: Need for Substantially Enhanced Spatial Resolution than Commonly Used in Brain MRI

Daniel Wenz¹, Andre Kuehne², Till Huelnhagen¹, Armin M. Nagel^3,4, Helmar Waiczies², Oliver Stachs⁵, Erdmann Seeliger⁶, Bert Flemming⁶, and Thoralf Niendorf^1,2

¹Berlin Ultrahigh Field Facility, Max Delbrueck Centrum, Berlin, Germany, ²MRI.TOOLS GmbH, Berlin, Germany, ³Institute of Radiology, Unviersity Hospital Erlangen, Erlangen, Germany, ⁴Division of Medical Physics in Radiology, German Research Centre (DKFZ), Heidelberg, Germany, ⁵Department of Ophthalmology, University of Rostock, Rostock, Germany, ⁶Institute of Physiology, Charite University Medicine, Berlin, Germany

Sodium ions are crucial in the physiology of human eye and its compartments like vitreous humor, aqueous humor, lens and retina. In this work we used a six-channel transceiver array dedicated for ocular ²³Na MRI and obtained in vivo images of the eye of exceptional quality with enhanced spatial resolution like (1.0x1.0x1.0) mm³ and demonstrated why spatial resolutions currently used for sodium MRI of the human brain are not sufficient in the context of ²³Na in vivo MRI of the human eye. Enhancing spatial resolution is essential to investigate changes of sodium concentration in subtle eye compartments (aqueous humor, lens).

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