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Abstract #1800

Tag-Based CSF Imaging Performance in Pediatric Patients and Adult Volunteers

Jieun Kwak1,2, Tai-Wei Wu1, Skorn Ponrartana3,4,5, Benita Tamrazi3,5, Wende Gibbs5, Thomas Chavez1, William Bradley6, Marvin D Nelson3,5, J. Gordon McComb7,8, Stefan Blüml3,4, and Matthew Borzage1,3,4

1Center for Fetal and Neonatal Medicine, Division of Neonatology | Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, Los Angeles, CA, United States, 2USC/LAC+USC Neonatal-Perinatal Medicine Fellowship Program, Division of Neonatology LAC+USC Medical Center & Children’s Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA, Los Angeles, CA, United States, 3Department of Radiology, Children’s Hospital Los Angeles, Los Angeles, CA, Los Angeles, CA, United States, 4Rudi Schulte Research Institute, Santa Barbara, CA, Santa Barbara, CA, United States, 5Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, Los Angeles, CA, United States, 6Department of Radiology, University of California San Diego, La Jolla, CA, La Jolla, CA, United States, 7Division of Neurosurgery, Children’s Hospital Los Angeles, Los Angeles, CA, Los Angeles, CA, United States, 8Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles CA, Los Angeles, CA, United States

We compared tag-based CSF imaging techniques (TimeSLIP and TimeSTAMP) in 10 healthy adults and 19 pediatric patients with cerebrospinal fluid (CSF) abnormalities. In adults, TimeSLIP and TimeSTAMP contrasts were quantitatively compared. TimeSTAMP sequences showed higher contrasts with decreased contrast variability versus TimeSLIP sequences. In pediatric patients, TimeSTAMP sequences were acquired to observe clinical utility and had similar contrast to the healthy adults. TimeSTAMP may be a superior imaging technique with clinical implications in adults and pediatric patients.

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