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Abstract #1801

Factor analysis to determine white matter injury patterns following pediatric traumatic brain injury.

Brenda Bartnik Olson1, Nirmalya Ghosh2, Udo Oyoyo1, Barbara Holshouser1, Joy Nichols2, Jamie Pivonka-Jones2, Karen Tong1, and Stephen Ashwal2

1Radiology, Loma Linda University Medical Center, Loma Linda, CA, United States, 2Pediatrics, Loma Linda University Medical Center, Loma Linda, CA, United States

Several studies have shown regional disruptions in white matter integrity following TBI although conventional methods don't account for the relationship between regions. In this study we used factor analysis, a data reduction technique, to identify patterns of WM injury that are associated with neurocognitive outcome in pediatric TBI patients. Our findings identified 3 dominant patterns of WM injury in pediatric TBI patients, describing regional changes in: 1) subcortical + cortical diffusivity, 2) subcortical diffusivity, and 3) subcortical + cortical anisotropy. Factor analysis provides a unique statistical approach to analyze DTI data and potentially could be used to combine different data streams (DTI, MR spectroscopy, SWI) representing different elements of injury.

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