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Abstract #1802

Structural MRI derived connectivity in Paediatric Mild Traumatic Brain Injury: Acute Neuroimaging and its relationship with executive function outcomes

Daniel J King1, Stefano Seri1, Vicki Anderson2, Cathy Catroppa2, Miriam H Beauchamp3, and Amanda G Wood1,4

1Aston Brain Center & School of Life and Health Sciences, Aston University, Birmingham, United Kingdom, 2Clinical Sciences, Murdoch Childrens Research Institute, Melbourne, Australia, 3Department of Psychology, University of Montreal, Montreal, QC, Canada, 4Murdoch Childrens Research Institute, Melbourne, Australia

The aim of the current study was to identify acute differences in the topology of the structural covariance network of children after a mild traumatic brain injury (TBI). This was to assess the potential utility of this connectivity analysis applied to T1-weighted MR images, novel in the TBI literature. The main findings of this study were i) both patients and controls exhibited typical frequency distribution of few, highly connected nodes, ii) at a group level, patients exhibited connections between nodes a greater distance apart, iii) these differences were not associated with differences in executive function outcome. Future work will have to move to individual-level SCNS to allow for more complex analyses and to enable investigation of more subtle individual differences in structural covariance.

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