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Abstract #1803

Morphological interrelationships in mid-line white-matter structures are altered in individuals carrying rare neuropsychiatric copy number variants.

Mark Drakesmith1,2, Greg D Parker1, Jacqueline Smith 2, Elliot Rees2, Michael Owen2, Derek K Jones1,2, and David E Linden2

1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom

Neuropsychiatric copy number variants (CNVs) provide unique insights into the genetic basis of neuropsychiatric disorders. This study utilised a novel approach for characterising morphology of white-matter fibres and combines them with more traditional volumetric and microstructural indices of white-matter to study their relation to penetrance for psychopathology in a CNV cohort. Results show cingulum morphology is significantly affected by the presence of CNVs with high-penetrance for schizophrenia and developmental disorders. Additionally, volumetric interrelationships across several white-matter structures are also altered. In particular, the ratios of tract volumes across segments of the corpus callosum are altered. It is likely that both these effects stem from a single neurodevelopmental trajectory characteristic of neuropsychiatric CNVs.

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