Abstract #2262

In vivo measurements of T1-dispersion maps in a kidney tumor mouse model using FFC-MRI around 1.5 T

Nicolas Chanet¹, Geneviève Guillot¹, Ingrid Leguerney^2,3, Rose-Marie Dubuisson¹, Catherine Sebrié¹, Alexandre Ingels^2,4, Noémie Assoun⁵, Estelle Daudigeos-Dubus⁵, Birgit Geoerger⁵, Nathalie Lassau^2,3, Lionel Broche⁶, and Ludovic de Rochefort⁷

¹IR4M UMR8081 Univ Paris-Sud CNRS, Université Paris Saclay, Orsay, France, ²IR4M UMR8081 Univ Paris-Sud CNRS, Université Paris Saclay, Villejuif, France, ³Gustave Roussy, Villejuif, France, ⁴Département d’Urologie – Institut Mutualiste Montsouris, Paris, France, ⁵Gustave Roussy, Vectorology and Anticancer Therapies, UMR8203 CNRS Univ Paris-Sud, Université Paris-Saclay, Villejuif, France, ⁶Bio-Medical Physics, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom, ⁷CRMBM UMR7339 CNRS Aix-Marseille Université, Marseille, France

Fast Field Cycling MRI offers the possibility to explore new contrasts generated from NMR dispersion (NMRD) profiles of tissue. Exploiting the dispersion properties of tissues may provide an additional biomarker of diseases through a deeper understanding of molecular mobility. Kidney tumors and healthy kidneys were analyzed among a cohort of twenty-seven mice to give insight into the potential of FFC-MRI for clinical applications. Here, we present R₁-dispersion maps performed around 1.5 T to show that the intrinsic dispersion of tumors measured in vivo differs from the one of healthy kidneys.

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