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Abstract #2262

In vivo measurements of T1-dispersion maps in a kidney tumor mouse model using FFC-MRI around 1.5 T

Nicolas Chanet1, Geneviève Guillot1, Ingrid Leguerney2,3, Rose-Marie Dubuisson1, Catherine Sebrié1, Alexandre Ingels2,4, Noémie Assoun5, Estelle Daudigeos-Dubus5, Birgit Geoerger5, Nathalie Lassau2,3, Lionel Broche6, and Ludovic de Rochefort7

1IR4M UMR8081 Univ Paris-Sud CNRS, Université Paris Saclay, Orsay, France, 2IR4M UMR8081 Univ Paris-Sud CNRS, Université Paris Saclay, Villejuif, France, 3Gustave Roussy, Villejuif, France, 4Département d’Urologie – Institut Mutualiste Montsouris, Paris, France, 5Gustave Roussy, Vectorology and Anticancer Therapies, UMR8203 CNRS Univ Paris-Sud, Université Paris-Saclay, Villejuif, France, 6Bio-Medical Physics, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom, 7CRMBM UMR7339 CNRS Aix-Marseille Université, Marseille, France

Fast Field Cycling MRI offers the possibility to explore new contrasts generated from NMR dispersion (NMRD) profiles of tissue. Exploiting the dispersion properties of tissues may provide an additional biomarker of diseases through a deeper understanding of molecular mobility. Kidney tumors and healthy kidneys were analyzed among a cohort of twenty-seven mice to give insight into the potential of FFC-MRI for clinical applications. Here, we present R1-dispersion maps performed around 1.5 T to show that the intrinsic dispersion of tumors measured in vivo differs from the one of healthy kidneys.

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