Abstract #2581

Validation of goose liver fat measurement by CSE-MRI with biochemical extraction as reference

Li Xu¹, Yangyang Duanmu¹, Xiaoqi Wang², Glen M Blake³, Peng Wang⁴, Manling Zhang⁵, Chao Wang⁶, and Xiaoguang Cheng¹

¹Department of Radiology, Beijing Jishuitan Hospital, Beijing, China, ²Philips Healthcare, Beijing, China, ³Biomedical Engineering Department, King’s College London, London, United Kingdom, ⁴Department of Pathology, Capital Medical University Affiliated Beijing Ditan Hospital, Beijing, China, ⁵China national food & safety supervision and inspection center, Beijing, China, ⁶Department of Statistics, Beijing Jishuitan Hospital, Beijing, China

This study aimed to validate chemical shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis. Twenty-two geese with a wide range of hepatic steatosis were collected, and proton density fat fraction by MRI (MRI-PDFF), biochemical triglyceride content, and histology were performed within the left lobe, upper and lower half of the right lobe of the geese livers. MRI correlated highly with chemical extraction (r = 0.949 (p ＜ 0.001)). Chemically extracted triglyceride was accurately predicted by MRI-PDFF (Y = -1.8 + 0.773﹡X). In conclusion, CSE-MRI measurement of goose liver fat was accurate and reliable compared with biochemical measurement.

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