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Abstract #2582

Relationship between Proton Density Fat Fraction and Liver Triglyceride Composition estimated by 1H MR Spectroscopy

Gavin Hamilton1, Alexandra N Schlein1, Adrija Mamidipalli1, Yesenia Covarrubias1, Jonathan C Hooker1, Walter C Henderson1, Ethan Z Sy 1, Jennifer Y Cui1, Rohit Loomba2, and Claude B Sirlin1

1Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, CA, United States, 2NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA, United States

Liver triglyceride composition was estimated using 1H MRS and compared to MRS estimated Proton Density Fat fraction (PDFF) to see if liver fat composition changes with PDFF. STEAM liver spectra were acquired in 263 adult subjects at 3 Tesla using breath-held, long-TR, multi-TE MRS to estimate PDFF and respiratory gated water-sated single TE MRS to estimate triglyceride composition. There is a significant change in the triglyceride composition of liver with changing PDFF, with the liver fat becoming more saturated as PDFF increases.

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