Abstract #2582

Relationship between Proton Density Fat Fraction and Liver Triglyceride Composition estimated by 1H MR Spectroscopy

Gavin Hamilton¹, Alexandra N Schlein¹, Adrija Mamidipalli¹, Yesenia Covarrubias¹, Jonathan C Hooker¹, Walter C Henderson¹, Ethan Z Sy ¹, Jennifer Y Cui¹, Rohit Loomba², and Claude B Sirlin¹

¹Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, CA, United States, ²NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA, United States

Liver triglyceride composition was estimated using ¹H MRS and compared to MRS estimated Proton Density Fat fraction (PDFF) to see if liver fat composition changes with PDFF. STEAM liver spectra were acquired in 263 adult subjects at 3 Tesla using breath-held, long-TR, multi-TE MRS to estimate PDFF and respiratory gated water-sated single TE MRS to estimate triglyceride composition. There is a significant change in the triglyceride composition of liver with changing PDFF, with the liver fat becoming more saturated as PDFF increases.

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