Abstract #2611

Early Stage Chronic Liver Disease: T1 Relaxation and Hepatic Fibrosis

Markus Karlsson¹, Thobias Romu^2,3, Amir Razavi⁴, Nils Dahlström⁵, Mikael F Forsgren⁶, Olof Dahlqvist-Leinhard^3,7, Bengt Norén⁶, Mattias Ekstedt⁸, Stergios Kechagias⁸, and Peter Lundberg¹

¹Department of Radiation Physics, and Department of Medical and Health Sciences and Center for Medical Image Science and Visualization (CMIV), Linköping Univeristy, Linköping, Sweden, ²Department of Biomedical Engineering and Center For Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ³Amra AB, Linköping, Sweden, ⁴Department of Radiology, and Department of Medical and Health Sciences, Linköping University, Norrköping, Sweden, ⁵Department of Medical and Health Sciences and Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ⁶Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ⁷Department of Medical and Health Sciences and Center for Medical Image Science and Visualization (CMIV), Linköping Univeristy, Linköping, Sweden, ⁸Department of Medical and Health Sciences and Department of Gasteroenterology and Hepatology, Linköping University, Linköping, Sweden

We measured T1 relaxation times in a prospectively recruited cohort of patients with suspected chronic liver disease. Our aim was to investigate the predictive value of T1 for staging hepatic fibrosis. Furthermore, we sought to test if T1 values are confounded by inflammation or presence of iron. We found that T1 was confounded by iron and that T1 alone had a poor ability to stage hepatic fibrosis.

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