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Abstract #2611

Early Stage Chronic Liver Disease: T1 Relaxation and Hepatic Fibrosis

Markus Karlsson1, Thobias Romu2,3, Amir Razavi4, Nils Dahlström5, Mikael F Forsgren6, Olof Dahlqvist-Leinhard3,7, Bengt Norén6, Mattias Ekstedt8, Stergios Kechagias8, and Peter Lundberg1

1Department of Radiation Physics, and Department of Medical and Health Sciences and Center for Medical Image Science and Visualization (CMIV), Linköping Univeristy, Linköping, Sweden, 2Department of Biomedical Engineering and Center For Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Amra AB, Linköping, Sweden, 4Department of Radiology, and Department of Medical and Health Sciences, Linköping University, Norrköping, Sweden, 5Department of Medical and Health Sciences and Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 6Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 7Department of Medical and Health Sciences and Center for Medical Image Science and Visualization (CMIV), Linköping Univeristy, Linköping, Sweden, 8Department of Medical and Health Sciences and Department of Gasteroenterology and Hepatology, Linköping University, Linköping, Sweden

We measured T1 relaxation times in a prospectively recruited cohort of patients with suspected chronic liver disease. Our aim was to investigate the predictive value of T1 for staging hepatic fibrosis. Furthermore, we sought to test if T1 values are confounded by inflammation or presence of iron. We found that T1 was confounded by iron and that T1 alone had a poor ability to stage hepatic fibrosis.

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