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Abstract #2765

Analysis of magnetization transfer (MT) effect on Bloch-simulation based T2 mapping accuracy, demonstrated on in vitro urea phantom

Dvir Radunsky1 and Noam Ben-Eliezer1,2,3

1Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 2Center for Advanced Imaging Innovation and Research, New York University, New York, NY, United States, 3Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

Accurate quantification of T2 values hold high value for a variety of clinical and research applications, yet is highly challenged by the inherent bias of rapid multi-SE (MSE) protocols due to stimulated and indirect echoes. Recently, we introduced the echo modulation curve (EMC) algorithm, which successfully overcomes this problem to produce accurate quantification of T2 values that are stable across scanners and scan settings. In this work, we investigate the effect of magnetization transfer on MSE signal, and specifically on EMC-derived T2 values for different T2 baselines, number of slices, and slice gaps, using an in vitro urea model.

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