The parameters estimated in DCE-MRI studies vary greatly depending on the arterial input function. Moreover, a more complex model than the extended Tofts’ model (ETM) is needed in glioma patients. In this work, a method to generate a voxel-specific input function (VIF) is introduced and used with a two-tissue compartment model (2TCM) that separates the fast and slow kinetics of the Gd contrast agent. The VIF provided more accurate results in the superior sagittal sinus (SSS) than the internal carotid artery and combined with the 2TCM, significantly improved the fits to the tumour over the ETM using the SSS.
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