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Abstract #2922

Assessment of Myocardial Fiber Orientation Using Diffusion Tensor Imaging in Patients with Hypertrophic Cardiomyopathy and Its Correlation with Echocardiographic Strain

Sang-Eun Lee1,2, Christopher Nguyen2,3, Sen Ma2,4, Debiao Li2,4, and Hyuk-Jae Chang1

1Yonsei University College of Medicine, Seoul, Republic of Korea, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 4Department of Bioengineering, University of California, Los Angeles, CA, United States

In hypertrophic cardiomyopathy, myocardial fiber disarray, and interstitial fibrosis interfere with regional systolic myocardial function despite clinically hyperdynamic systolic function. We quantitatively assessed the difference in myocardial fiber orientation between diseased and normal cardiac segments using diffusion tensor imaging. Further, these fiber microstructure were compared to the regional global longitudinal strain to evaluate whether the structure-function relationship changes according to the disease involvement.

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