Cardiac T2 mapping is a proven imaging test for myocardial tissue characterization. Standard cardiac T2 mapping involved in cardiac MRI protocol requires a breath-hold duration of 10 sec and usually samples three short-axis planes of the heart. This limited spatial coverage may miss the focal lesion. In this study, we developed a single-shot cardiac T2 mapping pulse sequence and reconstructed multiple T2-weighted images from a single T2-decay data, using k-Space weighted image contrast and compressed sensing technique. We tested its performance in patients with suspected infiltrative cardiomyopathy, and it yielded 7.9% difference in myocardial T2 values compared to standard T2 mapping.