This study applies a previously developed imaging-modelling approach to investigate the subject-specific effects of dobutamine on left ventricular contraction and relaxation patterns in healthy subjects. We created personalized models for nine subjects at rest and under dobutamine stress. The personalized parameter values were in agreement with the effects of inotropy and lusitropy reported in previous studies, and demostrated the anticipated variability in individual responses to dobutamine. With further validation, the given approach has the potential to generate advanced metrics of cardiovascular physiology and pathophysiology that could extend beyond conventional techniques for both diagnosis and optimization of a personalized medical regimen.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords