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Abstract #3052

Application of a novel 13C hyperpolarized metabolic tracer for γ-Glutamyl transferase activity in vivo tumor xenograft

Tomohiro Seki1, Marino Itoda2, Shun Kishimoto1, Kazu Yamamoto1, Yoichi Takakusagi3, Jeffery Brender1, Ronja M. Malinowski4, Tatsuya Nishihara2, Hikari A. I. Yoshihara5, Hiroshi Nonaka2, Keita Saito1, Nobu Oshima1, Jan H. Ardenkjaer-Larsen4, James B. Mitchell1, Murali C. Krishna1, and Shinsuke Sando2

1Radiation Biology Branch, CCR, NCI, NIH, Bethesda, MD, United States, 2Department of Chemistry and Biotechnology, Graduate School of Engineering, UT, Bunkyo-ku, Tokyo, Japan, 3Department of Molecular Imaging & Theranostics, QST, Chiba-shi, Japan, 4Electrical Engineering, Department of Electrical Engineering, DTU, Lyngby, Denmark, 5Institute of Physics of Biological Systems, EPFL, Lausanne, Swaziland

This research aimed to develop the non-invasive in vivo detection of γ-glutamyl transferase (GGT) activity by a novel GGT molecular probe, γ-Glu-[1-13C]Gly, in combination with hyperpolarized (HP) 13C Magnetic Resonance (MR) spectroscopy. We succeed in detecting the strong HP 13C MR signal of γ-Glu-[1-13C]Gly from tumor xenograft in vivo. Detecting HP 13C MR signal from the metabolite of this novel probe in tumor xenograft is our next challenge.

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