Atopic dermatitis (AD) is a chronic inflammatory condition with complex etiology. Redox imbalance caused by excessive oxidative stress has been shown to mediate disease activity of AD. We have established such a technique that can detect and visualize the redox status of the skin using in vivo dynamic nuclear polarization(DNP) MRI. We utilized an AD mouse model that was generated by repeated topical application of mite antigen in NC/Nga mice. We revealed that AD skin lesions demonstrated more rapid reduction rates of image intensity than normal skin, indicating that our technique can monitor oxidative stress in AD skin.
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