Abstract #3182

Comparing MEGA editing techniques for in-vivo measurement of 2-hydroxyglutarate

Ross Callaghan¹, Bhavana Solanky², Sotirios Bisdas¹, Hui Zhang¹, and Enrico De Vita¹

¹University College London, London, United Kingdom, ²Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom

MEGA-semiLASER is compared to a previously proposed MRS sequence for 2HG detection, MEGA-PRESS. The sequences are assessed using simulations of SNR with TE and the chemical shift displacement error (CSDE). Both sequences are shown to maximise 2HG SNR at TE of approximately 100ms. MEGA-semiLASER displays marginally higher SNR whilst reducing the CSDE of MEGA-PRESS. MEGA-semiLASER should offer a comparable reduction in CSDE to another proposed sequence, MEGA-LASER, whilst requiring fewer refocusing pulses and thus a lower SAR.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.