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Abstract #3182

Comparing MEGA editing techniques for in-vivo measurement of 2-hydroxyglutarate

Ross Callaghan1, Bhavana Solanky2, Sotirios Bisdas1, Hui Zhang1, and Enrico De Vita1

1University College London, London, United Kingdom, 2Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom

MEGA-semiLASER is compared to a previously proposed MRS sequence for 2HG detection, MEGA-PRESS. The sequences are assessed using simulations of SNR with TE and the chemical shift displacement error (CSDE). Both sequences are shown to maximise 2HG SNR at TE of approximately 100ms. MEGA-semiLASER displays marginally higher SNR whilst reducing the CSDE of MEGA-PRESS. MEGA-semiLASER should offer a comparable reduction in CSDE to another proposed sequence, MEGA-LASER, whilst requiring fewer refocusing pulses and thus a lower SAR.

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