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Abstract #3222

Transient anomalous diffusion micro-MRI parameters reflect white matter morphology: comparison with histology of the mouse spinal cord.

Alessandra Caporale1, Giovanni Battista Bonomo2, Giulio Tani2, AdaMaria Tata3, Bice Avallone4, Felix Werner Wehrli5, and Silvia Capuani1

1Physics, CNR ISC, UOS Roma Sapienza, Sapienza University of Rome, Rome, Italy, 2Physics, Biophysics division, Sapienza University of Rome, Rome, Italy, 3Biology and Biotechnologies C. Darwin, Research Center of Neurobiology Daniel Bovet, Sapienza University of Rome, Rome, Italy, 4Biology, University of Naples Federico II, Naples, Italy, 5Radiology, Laboratory for Structural, Physiologic and Functional Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Transient-anomalous diffusion (tAD) has previously been used for tumor delineation and human brain tissue characterization, however, comparison with histology is largely missing. This work aims to compare α and γ tAD parameters, DTI and q-space-imaging parameters obtained at 9.4T with micro-MRI, with the morphologic characteristics provided by optical microscopy of mouse spinal cord white matter (MSC-wm). We found that γ- and q-space-imaging are sensitive to axon diameter and effective local axon density, while α-imaging is sensitive to the heterogeneity or degree of disorder of the wm tracts. These techniques outperform DTI as a means to probe MSC-wm morphology.

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