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Abstract #3241

Oscillating gradient spin echo (OGSE) diffusion weighted imaging of the epidermoid cysts: simulation application

Saori Koshino1,2, Akiyuki Sakakibara3, Antoine Choppin3, Christina Andica1, Akifumi Hagiwara1,2, Tomoko Maekawa1,2, Mihiro Takemori1,4, Atsushi Arakawa5, Lydia Chougar1,6, Masaaki Hori1, and Shigeki Aoki1

1Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, 2Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 3LPixel Inc., Tokyo, Japan, 4Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 5Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan, 6Hôpital Cochin, Paris, France

Diffusion weighted imaging with shorter diffusion time using oscillating gradient spin echo (OGSE) may reveal microstructural features among brain disorders. Here we observed apparent diffusion coefficient (ADC) values in three patients with intracranial epidermoid cysts. ADC values measured by OGSE were higher than those measured by pulsed gradient spin echo (PGSE; used in conventional MRI), indicating restricted diffusion due to spatial restriction. The results of our diffusion simulation based on the pathological feature of epidermoid cysts suggest that spatial restriction of “Rugby Ball” regions formed by keratin layers should mainly affect the extent of restricted diffusion.

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