Abstract #3241

Oscillating gradient spin echo (OGSE) diffusion weighted imaging of the epidermoid cysts: simulation application

Saori Koshino^1,2, Akiyuki Sakakibara³, Antoine Choppin³, Christina Andica¹, Akifumi Hagiwara^1,2, Tomoko Maekawa^1,2, Mihiro Takemori^1,4, Atsushi Arakawa⁵, Lydia Chougar^1,6, Masaaki Hori¹, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan, ²Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ³LPixel Inc., Tokyo, Japan, ⁴Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, ⁵Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan, ⁶Hôpital Cochin, Paris, France

Diffusion weighted imaging with shorter diffusion time using oscillating gradient spin echo (OGSE) may reveal microstructural features among brain disorders. Here we observed apparent diffusion coefficient (ADC) values in three patients with intracranial epidermoid cysts. ADC values measured by OGSE were higher than those measured by pulsed gradient spin echo (PGSE; used in conventional MRI), indicating restricted diffusion due to spatial restriction. The results of our diffusion simulation based on the pathological feature of epidermoid cysts suggest that spatial restriction of “Rugby Ball” regions formed by keratin layers should mainly affect the extent of restricted diffusion.

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