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Abstract #3675

Contrast Agent Assessment: Comparison of Quantitative Techniques

Matthew Tarasek1, Jeannette Roberts2, Deirdre Cassidy 3, Jason Castle2, Concetta Gringeri3, Desmond Yeo1, Randall Carter2, and Brian Bales2

1MRI, GE Global Research, Niskayuna, NY, United States, 2Life Sciences, GE Global Research, Niskayuna, NY, United States, 3Life Sciences, GE Healthcare UK, United Kingdom, United Kingdom

Contrast agents are widely used in magnetic resonance imaging (MRI) examinations to enhance the visualization of certain pathologies and anatomical structures to improve diagnostic accuracy. Contrast agents shorten the longitudinal relaxation time (T1) of water molecules, and subsequent signal enhancement in T1-weighted (T1W) images can be observed. In this work, we compare quantitative T1W imaging and T1 mapping for detection of contrast agent deposition in select rat brain structures. Results are presented for two distinct brain structures in a cohort of six rats: three saline controls and three injected with manganese chloride contrast agent.

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