Contrast agents are widely used in magnetic resonance imaging (MRI) examinations to enhance the visualization of certain pathologies and anatomical structures to improve diagnostic accuracy. Contrast agents shorten the longitudinal relaxation time (T1) of water molecules, and subsequent signal enhancement in T1-weighted (T1W) images can be observed. In this work, we compare quantitative T1W imaging and T1 mapping for detection of contrast agent deposition in select rat brain structures. Results are presented for two distinct brain structures in a cohort of six rats: three saline controls and three injected with manganese chloride contrast agent.
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