Altered cognitive performance is well known in both hypothyroidism and hyperthyroidism but little is known about deficits in brain functions in Subclinical hypothyroidism (SCH). Aim of the present study was to investigate the metabolic changes in Dorso-Lateral Pre-Frontal Cortex (DLPFC) of SCH patients using 1H MRS. 19 freshly diagnosed SCH patients and 24 age matched healthy controls were recruited and subjected to MRS. Our result show significantly increased concentrations of GSH (p<0.009) and creatine (p<0.017) in the DLPFC and diminished cognitive performance in SCH compared to controls. The increase in the level of GSH in SCH compared to controls may be indicative of an initial compensatory, neuro-protective response due to oxidative stress.
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