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Abstract #3788

Aberrant Brain Iron Deposition in Gray Matter Nuclei and Hippocampus in Alzheimer Disease with Type 2 Diabetes Mellitus: A Quantitative Susceptibility Mapping Study

Xiaoxin Li1, Yanwei Miao1, Liang Han1, Junyi Dong1, and Qingwei Song1

1The First Affiliated Hospital of Dalian Medical University, Dalian, China

In this study, brain iron contents in basal nuclei, thalamus and hippocampus of AD+T2DM patients and AD-T2DM patients was quantified with susceptibility values by QSM, and further to explore the correlation between brain iron deposition and cognition level and clinical factors. From the study results, we conclude that the susceptibility values were generally decreased due to aberrant iron deposition in gray matter nuclei in AD+T2DM patients relative to AD-T2DM patients. The susceptibility values of right GP has a better correlation with cognition, which administers to monitor the development of cognitive impairment.

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