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Abstract #3907

Metabolic basis of (de)activation fMRI paradigms: J-edited lactate and diffusion-weighted water 1H-MRS

Yury Koush1, Robin A. de Graaf1, Ron Kupers2, Laurence Dricot3, Douglas L. Rothman1, and Fahmeed Hyder1

1MRRC, Yale University, New Haven, CT, United States, 2Department of Clinical Neurophysiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 3Institute of Neuroscience, University of Louvain, Brussels, Belgium

During task-based versus rest epochs, the BOLD signal increases in a task-positive region (activation paradigm) and decreases in a task-negative region (deactivation paradigm), also known as the default mode network (DMN). We investigated the metabolic basis of (de)activation paradigms using concurrent 1H-MRS acquisitions of J-edited lactate and diffusion-weighted water. Using (de)activation paradigms, we detected associated increase of water (i.e., BOLD signal) and lactate in visual cortex (non-DMN area), whereas in posterior cingulate cortex (DMN area) water decreased but lactate did not change. These results suggest similar degrees of aerobic glycolysis in both DMN and non-DMN areas.

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