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Abstract #3908

Neurochemical profiling in the rat model of Tourette’s Syndrome @ 11.7T

Alireza Abaei1, Francesca Rizzo2,3, Dinesh K Deelchand4, Tobias M. Böckers2, and Volker Rasche1

1Core Facility Small Animal Imaging, Ulm University, Ulm, Germany, 2Institute of Anatomy and Cell Biology, Ulm University, Ulm, Germany, 3Department of Child and Adolescent Psychiatry, Ulm University, Ulm, Germany, 4Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Tourette’s syndrome (TS) is a neurodevelopmental disorder characterized primarily by motor tics probably due to dysfunctions of the cortico-striato-thalamic-cortical loop (CSTC) but the underlying molecular reason why tic occur is not yet known. In this study, a dedicated optimized STEAM sequence with single-shot phase and frequency correction, and image-based shimming was applied to uncover the metabolic “signature” of a tic using in vivo 1H-MRS at 11.7T. Despite a clear ticking phenotype observed in our animal model, the unaltered striatal neurochemical profile suggest questions on the role of the striatum within the supposed dysfunctional cortical-striatal-thalamic-cortico circuitry in TS.

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