Abstract #4447

Effectiveness of 6 monthly MRI screening for breast cancer in women with a BRCA mutation – a numerical simulation.

Keith S Cover¹, Joost PA Kuijer¹, Mark MB Hofman¹, Jeroen Veltman², Monique D Dorrius³, Ritse M Mann⁴, and Katya M Duvivier¹

¹VU University Medical Center, Amsterdam, Netherlands, ²ZGT Hengelo, Hengelo, Netherlands, ³University Medical Center Groningen, Groningen, Netherlands, ⁴Radboud University Medical Center, Nijmegen, Netherlands

Currently, MRI screening for breast cancer in women with a BRCA mutation is annually. However, studies on tumour doubling times indicate that some tumours grow faster. To assess the value of more frequent screening we numerically simulated annual and 6 monthly screening based on reported tumour doubling times in women with the BRCA mutation. For annual screening, the simulation predicted 14% of cancers with poor prognosis (diameter > 2 cm), in line with clinical studies. For 6 monthly screening the simulation predicted 3% with poor prognosis. Therefore, 6 monthly screening should yield a substantial reduction in tumours with a poor prognoses .

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.