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Abstract #4510

Simultaneous fMRI and electrophysiology: measuring local field potential, multi-unit, and single unit activity

Brittany M Katz1, Tzu-Hao Chao2, Mike Sorenson 3, You-Yin Chen4, Yen-Yu Ian Shih2, and SungHo Lee2

1Neuroscience Curriculum, University of North Carolina Chapel Hill, Chapel Hill, NC, United States, 2Neurology, University of North Carolina Chapel Hill, Chapel Hill, NC, United States, 3Engineering, Blackrock Microsystems, Salt Lake City, UT, United States, 4Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan

The use of hemodynamic signals as a surrogate measure of neuronal activity presents a major challenge to any straightforward interpretation of fMRI data. In recognition of this caveat, this study describes a polyimide-based MR-compatible microelectrode array with a MR-compatible headstage preamplifier and demonstrates the feasibility in vivo for recording of BOLD, LFP, MUA, and single-unit activity simultaneously.

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