Abstract #4510

Simultaneous fMRI and electrophysiology: measuring local field potential, multi-unit, and single unit activity

Brittany M Katz¹, Tzu-Hao Chao², Mike Sorenson ³, You-Yin Chen⁴, Yen-Yu Ian Shih², and SungHo Lee²

¹Neuroscience Curriculum, University of North Carolina Chapel Hill, Chapel Hill, NC, United States, ²Neurology, University of North Carolina Chapel Hill, Chapel Hill, NC, United States, ³Engineering, Blackrock Microsystems, Salt Lake City, UT, United States, ⁴Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan

The use of hemodynamic signals as a surrogate measure of neuronal activity presents a major challenge to any straightforward interpretation of fMRI data. In recognition of this caveat, this study describes a polyimide-based MR-compatible microelectrode array with a MR-compatible headstage preamplifier and demonstrates the feasibility in vivo for recording of BOLD, LFP, MUA, and single-unit activity simultaneously.

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