Multiparametric MRI was used to assess folic acid-induced renal pathology in mice. Kidney volume, R2*, magnetization transfer ratio (MTR), perfusion, T1, and glomerular filtration rate (GFR) were measured at 2 and 4 weeks post-treatment. While kidney structure (volume and MTR) and hypoxia (R2*) showed progressive deterioration, renal perfusion and normalized GFR dropped dramatically at 2 weeks but recovered slightly at 4 weeks. T1 elevated at 2 weeks and slightly dropped at 4 weeks, suggesting development of transient edema. In conclusion, multiparametric MRI provides a valuable tool for investigation and monitoring of folic acid induced renal pathology.
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