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Abstract #4594

Multiparametric MRI of Folic Acid Induced Renal Pathology in Mice: A Longitudinal Study

Kai Jiang1, Tristan A. Ponzo1, Hui Tang1, Prasanna K. Mishra2, Slobodan I. Macura2, and Lilach O. Lerman1

1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States, 2Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States

Multiparametric MRI was used to assess folic acid-induced renal pathology in mice. Kidney volume, R2*, magnetization transfer ratio (MTR), perfusion, T1, and glomerular filtration rate (GFR) were measured at 2 and 4 weeks post-treatment. While kidney structure (volume and MTR) and hypoxia (R2*) showed progressive deterioration, renal perfusion and normalized GFR dropped dramatically at 2 weeks but recovered slightly at 4 weeks. T1 elevated at 2 weeks and slightly dropped at 4 weeks, suggesting development of transient edema. In conclusion, multiparametric MRI provides a valuable tool for investigation and monitoring of folic acid induced renal pathology.

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