Abstract #4594

Multiparametric MRI of Folic Acid Induced Renal Pathology in Mice: A Longitudinal Study

Kai Jiang¹, Tristan A. Ponzo¹, Hui Tang¹, Prasanna K. Mishra², Slobodan I. Macura², and Lilach O. Lerman¹

¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States, ²Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States

Multiparametric MRI was used to assess folic acid-induced renal pathology in mice. Kidney volume, R₂^*, magnetization transfer ratio (MTR), perfusion, T₁, and glomerular filtration rate (GFR) were measured at 2 and 4 weeks post-treatment. While kidney structure (volume and MTR) and hypoxia (R₂^*) showed progressive deterioration, renal perfusion and normalized GFR dropped dramatically at 2 weeks but recovered slightly at 4 weeks. T₁ elevated at 2 weeks and slightly dropped at 4 weeks, suggesting development of transient edema. In conclusion, multiparametric MRI provides a valuable tool for investigation and monitoring of folic acid induced renal pathology.

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