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Abstract #4820

Monitoring diabetic stroke response to novel p38 MAPK inhibitor therapy using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)

Yu Cai1 and Shenghong Ju1

1Department of Radiology, Zhongda Hospital,Medical School, Southeast University, Nanjing, China

We monitored the increased disruption of blood brain barrier (BBB) by DCE-MRI at acute-stage of ischemic stroke in T2DM mice non-invasively. Furthermore, administration of novel P38 inhibitor is a promising way to promote BBB recovery in diabetic stroke and the therapeutic efficacy can be monitored by DCE-MRI.

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