Abstract #4863

Late-delayed perfusion decrease following radiochemotherapy in glioblastoma patients

Jan Petr^1,2, Henri JMM Mutsaerts^2,3,4, Ivan Platzek⁵, Vera C Keil⁶, Frank Hofheinz¹, Iris Asllani², Annekatrin Seidlitz^7,8,9,10, Marketa Petrova⁵, Esther GC Troost^{7,8,9,10,11,12}, Mechthild Krause^{7,8,9,10,11,12}, and Jörg van den Hoff^1,13

¹PET Center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ²Rochester Institute of Technology, Rochester, NY, United States, ³Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, ⁵Department of Radiology, University Hospital Carl Gustav Carus, Dresden, Germany, ⁶University Hospital Bonn, Bonn, Germany, ⁷Department of Radiation Oncology, University Hospital Carl Gustav Carus, Dresden, Germany, ⁸OncoRay – National Center for Radiation Research in Oncology, Dresden, Germany, ⁹German Cancer Consortium (DKTK), Dresden, Germany, ¹⁰German Cancer Research Center (DKFZ), Heidelberg, Germany, ¹¹Institute of Radiooncology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ¹²NCT – National Center for Tumor Disease, Dresden, Germany, ¹³Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Dresden, Germany

Temozolomide-based radiochemotherapy (RCT) is a treatment standard for glioblastoma patients. However, RCT is associated with risks of neurocognitive decline. Perfusion is a possible early marker of tissue damage and has been shown to correlate with cognitive changes in many diseases. Perfusion decrease at 3 to 6 months after RT was recently reported in glioblastoma patients. However, it remains unclear whether the decrease is reversible and thus possibly a precursor of the late-delayed cognitive changes. In this study, we have measured perfusion changes up to 18 months following RCT. No further progress of perfusion deficits was found indicating that the early perfusion decrease is predictive of late perfusion decrease and might thus be connected with cognitive decline.

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