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Abstract #4863

Late-delayed perfusion decrease following radiochemotherapy in glioblastoma patients

Jan Petr1,2, Henri JMM Mutsaerts2,3,4, Ivan Platzek5, Vera C Keil6, Frank Hofheinz1, Iris Asllani2, Annekatrin Seidlitz7,8,9,10, Marketa Petrova5, Esther GC Troost7,8,9,10,11,12, Mechthild Krause7,8,9,10,11,12, and Jörg van den Hoff1,13

1PET Center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 2Rochester Institute of Technology, Rochester, NY, United States, 3Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 5Department of Radiology, University Hospital Carl Gustav Carus, Dresden, Germany, 6University Hospital Bonn, Bonn, Germany, 7Department of Radiation Oncology, University Hospital Carl Gustav Carus, Dresden, Germany, 8OncoRay – National Center for Radiation Research in Oncology, Dresden, Germany, 9German Cancer Consortium (DKTK), Dresden, Germany, 10German Cancer Research Center (DKFZ), Heidelberg, Germany, 11Institute of Radiooncology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 12NCT – National Center for Tumor Disease, Dresden, Germany, 13Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Dresden, Germany

Temozolomide-based radiochemotherapy (RCT) is a treatment standard for glioblastoma patients. However, RCT is associated with risks of neurocognitive decline. Perfusion is a possible early marker of tissue damage and has been shown to correlate with cognitive changes in many diseases. Perfusion decrease at 3 to 6 months after RT was recently reported in glioblastoma patients. However, it remains unclear whether the decrease is reversible and thus possibly a precursor of the late-delayed cognitive changes. In this study, we have measured perfusion changes up to 18 months following RCT. No further progress of perfusion deficits was found indicating that the early perfusion decrease is predictive of late perfusion decrease and might thus be connected with cognitive decline.

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