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Abstract #4874

Myocardial fibrosis evaluated by diffusion weighted imaging and and its relationship to three-dimensional global contractile function in patients with hypertrophic cardiomyopathy

Rui Wu1, Dong-Ao-Lei An1, Bing-Hua Chen1, Ruo-Yang Shi1, Wei-Bo Chen2, Tong-Tong Han3, Lian-Ming Wu1, and Jian-Rong Xu1

1Radiology, Ren Ji Hospital, School of Medicine,Shanghai Jiao Tong University, Shanghai, China, 2Philips Healthcare,shanghai, China, Shanghai, China, 3Clinical Application, Circle Cardiovascular Imaging, Calgary, Canada

The prognostic value of the apparent diffusion coefficient (ADC) for diffuse myocardial fibrosis and its relationship to the contractile function is still not investigated. A total of 45 HCM patients and 20 controls underwent a 3.0-T cardiac magnetic resonance imaging (CMRI), including cine, T1 mapping, and DWI. ADC values in the ECV ≥ 29.6% group were significantly increased compared to the ECV < 29.6% group. ADC values were linearly associated with 3D LV GCS, GLS, GCSR, GLSR and GRSR. Impairment of contractile function in HCM is predominantly associated with the contrast-free ADC value.

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