Abstract #4874

Myocardial fibrosis evaluated by diffusion weighted imaging and and its relationship to three-dimensional global contractile function in patients with hypertrophic cardiomyopathy

Rui Wu¹, Dong-Ao-Lei An¹, Bing-Hua Chen¹, Ruo-Yang Shi¹, Wei-Bo Chen², Tong-Tong Han³, Lian-Ming Wu¹, and Jian-Rong Xu¹

¹Radiology, Ren Ji Hospital, School of Medicine，Shanghai Jiao Tong University, Shanghai, China, ²Philips Healthcare，shanghai， China, Shanghai, China, ³Clinical Application, Circle Cardiovascular Imaging, Calgary, Canada

The prognostic value of the apparent diffusion coefficient (ADC) for diffuse myocardial fibrosis and its relationship to the contractile function is still not investigated. A total of 45 HCM patients and 20 controls underwent a 3.0-T cardiac magnetic resonance imaging (CMRI), including cine, T1 mapping, and DWI. ADC values in the ECV ≥ 29.6% group were significantly increased compared to the ECV < 29.6% group. ADC values were linearly associated with 3D LV GCS, GLS, GCSR, GLSR and GRSR. Impairment of contractile function in HCM is predominantly associated with the contrast-free ADC value.

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