Abstract #4875

Elevated NT-proBNP in a Community Cohort is Associated with Myocardial Fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)

Chia-Ying Liu¹, Susan R Heckbert², Shenghan Lai³, Bharath Amable-Venkatesh⁴, Mohammad R Ostovaneh⁴, Robyn L McClelland⁵, Joao A.C Lima⁴, and David A Bluemke⁶

¹Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, ²Department of Epidemiology, University of Washington, Seattle, WA, United States, ³Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, United States, ⁴Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States, ⁵Department of Biostatistics, University of Washington, Seattle, WA, United States, ⁶David Bluemke, University of Wisconsin, Madison, WI, United States

We evaluated the relationship between cardiac MRI measures of fibrosis and NT-proBNP levels in 1334 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Univariate and multivariable regression analyses adjusting for demographics, cardiovascular risk factors, and left ventricular (LV) mass were performed to examine the association of log NT-proBNP with MRI T1 mapping indices. In the fully adjusted model, each one standard deviation increment (0.44pg/mL) of log NT-proBNP was associated with 0.62% increment in ECV (P<0.001), 4.7ms increment in native T1 (P=0.001), and 0.01 increment in partition coefficient (P<0.001). Elevated NT-proBNP is related to subclinical fibrosis in a community-based setting.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.