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Abstract #4876

Myocardial Oxygenation Using T2* BOLD Cardiac MRI with Compressed SENSE: Association with Myocardial Fibrosis and Contraction in Hypertrophic Cardiomyopathy

Michinobu Nagao1, Kenji Fukushima1, Eri Watanabe2, Umiko Ishizaki1, Yuka Matsuo1, Akiko Sakai2, Risako Nakao2, Yasuhiro Goto3, Masami Yoneyama4, and Shuji Sakai1

1Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University, Tokyo, Japan, 2Cardiology, Tokyo Women's Medical University, Tokyo, Japan, 3Radiological service, Tokyo Women's Medical University, Tokyo, Japan, 4Philips Electronics Japan, Tokyo, Japan

We developed a new method for myocardial oxygenation using oxygen-inhalation blood-oxygen-level-dependent (BOLD) T2* cardiac magnetic resonance imaging (T2*-CMR). Myocardial oxygenation (ΔR2*, ms-1) was defined as the difference in R2* between under room-air and oxygen inhalation. ΔR2* is increased in patients with hypertrophic cardiomyopathy who had large LGE areas and low strains, suggesting that impairment of myocardial oxygenation associates with myocardial fibrosis and systolic dysfunction. In addition, T2*-CMR with compressed SENSE enables to shorten scan time and less motion artifact. This contributes to make high precision of T2* and R2* maps.

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