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Abstract #4949

Functional correlates of microstructural damage in developmental traumatic brain injury: a multi-modal MRI study of neuroanatomy, cerebrovascular reactivity, and functional connectivity

Maxime Parent1, Ying Li2, Basavaraju G. Sanganahalli1, Vijayalakshmi Santhakumar2, D.S. Fahmeed Hyder1, and Sridhar Kannurpatti3

1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Pharmacology, Physiology and Neurosciences, Rutgers New Jersey Medical School, Newark, NJ, United States, 3Radiology, Rutgers New Jersey Medical School, Newark, NJ, United States

The developing brain is particularly vulnerable to traumatic brain injury (TBI), with symptoms and co-morbidities lasting into adulthood. Animal models of developmental TBI are useful tools for investigating molecular pathways of TBI injuries and to assess novel therapeutics; however, validation of in vivo injury biomarkers in these models is important for the translational application of pre-clinical findings. Here, we demonstrate that the persistent dysfunctions of developmental TBI in an animal model can be measured at the level of microstructural damage (with diffusion MRI), functional interhemispheric connectivity (with resting-state fMRI) and systemic neurovascular coupling (with CO2 challenge fMRI).

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