The developing brain is particularly vulnerable to traumatic brain injury (TBI), with symptoms and co-morbidities lasting into adulthood. Animal models of developmental TBI are useful tools for investigating molecular pathways of TBI injuries and to assess novel therapeutics; however, validation of in vivo injury biomarkers in these models is important for the translational application of pre-clinical findings. Here, we demonstrate that the persistent dysfunctions of developmental TBI in an animal model can be measured at the level of microstructural damage (with diffusion MRI), functional interhemispheric connectivity (with resting-state fMRI) and systemic neurovascular coupling (with CO2 challenge fMRI).
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