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Abstract #5289

Accelerated Isotropic Sub-Millimeter Whole-Brain Susceptibility Imaging at 3T: Application to Multiple Sclerosis

Sunil Patil1, Henrik Odéen2, J. Andrew Derbyshire3, Gunnar Krueger4, Dennis L. Parker2, Himanshu Bhat5, Daniel S. Reich6, and Pascal Sati6

1Siemens Medical Solutions USA, Inc, Baltimore, MD, United States, 2Radiology and Imaging Sciences, University Of Utah, Salt Lake City, UT, United States, 3Section of Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, 4Siemens Healthcare, Zurich, Switzerland, 5Siemens Medical Solutions USA, Inc, Boston, MA, United States, 6Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

High-resolution susceptibility-weighted MRI has recently gained attention as a novel imaging biomarker in multiple sclerosis (MS) such as the ‘central vein sign’ and ‘phase rims’. This preliminary study demonstrates the feasibility of an accelerated volumetric (3D) segmented echo-planar-imaging (EPI) sequence, which allows acquiring whole brain images at 0.65 mm isotropic resolution in approximately 3 minutes. Both magnitude (T2*-weighted) and phase (QSM) information were interpretable and displayed characteristic features of MS lesions. This accelerated 3D EPI anatomical acquisition shows potential to open the door to routine high-resolution susceptibility-weighted imaging to better support diagnosis and therapy monitoring in MS patients.

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