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Abstract #5501

Varying diffusion effects in susceptibility-based myelin water imaging produce characteristic signal decay curves

Felix T Kurz1, Lukas R Buschle2, Martin Bendszus1, Christian H Ziener2, and Johann ME Jende1

1Heidelberg University Hospital, Heidelberg, Germany, 2German Cancer Research Center, Heidelberg, Germany

The biophysical origins of MR signal formation in uniform media such as an axon with its multilayered myelin envelope may produce signal characteristics that can be used to determine status and/or outcome of demyelinating disease. We extend a recently proposed model of neuronal magnetic susceptibility by including the whole dynamic range of diffusion effects to study gradient-echo MR signal decay. Our results may be used to adjust or control simulation studies on neuronal MR signal decay.

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