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Abstract #5503

3D inhomogeneous magnetization transfer and rapid gradient echo (ihMTRAGE) imaging

Gopal Varma1, Olivier M Girard2, Samira Mchinda2, Arnaud Guidon3, Dan W Rettmann4, Victor Carvalho2, Valentin H Prevost2, Pauline W Worters5, Marc R Lebel6, Guillaume Duhamel2, and David C Alsop1

1Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2CNRS, CRMBM, UMR 7339, Aix Marseille Universite, Marseille, France, 3GE Healthcare, Boston, MA, United States, 4GE Healthcare, Rochester, MN, United States, 5GE Healthcare, Menlo Park, CA, United States, 6GE Healthcare, Calgary, AB, Canada

The inhomogeneous magnetization transfer (ihMT) technique provides a myelin-sensitive signal and has been applied for 3D acquisition in the steady-state. Sequences applied in a segmented fashion, following some magnetization preparation, provide an advantage of allowing insertion of additional modules, e.g. motion correction. An ihMT acquisition in the style of the magnetization-prepared rapid gradient-echo sequence was designed based on considerations of safety, hardware and optimizing the ihMT signal. Whole brain 3D ihMT data with 2.4mm isotropic resolution was achieved in 6-7mins. IhMT ratios between 15-20% were measured in white matter areas, and were not significantly modified by inclusion of a prospective motion correction module.

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