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Abstract #5524

Reproducibility and quality assessment of a 3D-EPI Pulsed Arterial Spin Labelling scheme at 7 T in a clinical cohort

Richard J Dury1, Yasser Falah2, Penny A Gowland1, Nikos Evangelou2, Susan T Francis1, and Molly G Bright1,3

1Sir Peter Mansfield Imaging Centre, University on Nottingham, Nottingham, United Kingdom, 2Division of Clinical Neurology, University on Nottingham, Nottingham, United Kingdom, 3Clinical Neurology, University of Nottingham, Nottingham, United Kingdom

3D-EPI arterial spin labelling (ASL) at 7T has been shown to provide advantages over 2D-EPI, however its reproducibility has not been determined. Here we assess the data quality of 7T 3D-EPI pulsed ASL data in healthy volunteers (HV) and Multiple Sclerosis (MS) patients demonstrating significantly higher temporal SNR (tSNR) in MS patients. On comparing repeats from two scans, acquired ~3 weeks apart, we observe good reproducibility of CBF estimates with a coefficient of variation of 14.7% in HVs and 12.1% in MS patients. This ASL method can be used to evaluate perfusion longitudinally in clinical cohorts.

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