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Abstract #5525

Blood transit time heterogeneity (TTH) mapping in the human brain with multi-TI pCASL

Michael Germuska1, Thomas Okell2, and Richard Wise1

1Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, 2Wellcome Centre for Integrative Neuroimaging (FMRIB), Oxford University, Oxford, United Kingdom

A blood transit transit heterogeneity (TTH) mapping method is presented based on the regularised fitting of multi-TI pCASL data. The method applies a gamma variate dispersion model to account for upstream flow dispersion and tissue transit heterogeneity. The approach is shown to have sufficient sensitivity to distinguish a range of TTH times in gray matter and results are comparable with previous ROI based approaches. The mapping of TTH has the potential to be a sensitive marker for cerebrovascular dysfunction.

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