Abstract #0004

Using 129Xenon MR Imaging and Spectroscopic Signatures to Differentiate Pulmonary Arterial Hypertension from Other Cardiopulmonary Diseases

Elianna Ada Bier^1,2, Ziyi Wang^1,2, Aparna Swaminathan³, John Nouls², Mu He^2,4, Joseph Mammarappallil⁵, Sheng Lou⁶, Sudarshan Rajagopal⁷, and Bastiaan Driehuys^1,2,5

¹Biomedical Engineering, Duke University, Durham, NC, United States, ²Center for In Vivo Microscopy, Duke University, Durham, NC, United States, ³Department of Medicine, Duke University Medical Center, Durham, NC, United States, ⁴Electrical and Computer Engineering, Duke University, Durham, NC, United States, ⁵Radiology, Duke University Medical Center, Durham, NC, United States, ⁶Biostatistics & Bioinformatics, Duke University Medical Center, Durham, NC, United States, ⁷Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, United States

This work sought to identify a non-invasive means to detect pulmonary arterial hypertension (PAH). ¹²⁹Xenon MRI and dynamic spectroscopy were acquired in healthy volunteers and subjects with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), left heart failure (LHF), and PAH. COPD was differentiated from PAH by increased ventilation and barrier defects, while IPF was differentiated by increased barrier uptake. PAH and LHF subjects had similar imaging features but could be differentiated by their RBC signal oscillation amplitudes. ¹²⁹Xe MR imaging and spectroscopy appears capable of differentiating PAH from COPD, IPF, and LHF.

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